Expand universal databases

[Robaina]

Would be great to expand the BIGG database with additional reactions. Suggest checking other biochemical databases: ModelSEED, BioCyc, and align namespaces (e.g., metanetx).

Additionally, would be very useful to expand not only biochemical representation but enzyme sequence representation. Perhaps even use HMMs instead of blastx?

UPDATE:

modelSEED uses RAST annotations to link enzymes to genes, so a (prokaryotic) genome must be first annotated with RAST. For plants and funghi, they used a different annotation pipeline, specific to these groups. I only see ec numbers in their reactions.tsv file, though.