diff --git a/src/errors/checkXcmTxInputs.spec.ts b/src/errors/checkXcmTxInputs.spec.ts
index a5778124..b40a72d2 100644
--- a/src/errors/checkXcmTxInputs.spec.ts
+++ b/src/errors/checkXcmTxInputs.spec.ts
@@ -14,6 +14,7 @@ import {
 	checkAssetIdsLengthIsValid,
 	checkAssetsAmountMatch,
 	checkBridgeTxInputs,
+	checkDestAddrIsValid,
 	checkDryRunCallOptionIncludesSendersAddressAndXcmFeeAsset,
 	checkIfNativeRelayChainAssetPresentInMultiAssetIdList,
 	checkLiquidTokenTransferDirectionValidity,
@@ -903,6 +904,35 @@ describe('checkDryRunCallOptionIncludesSendersAddressAndXcmFeeAsset', () => {
 	});
 });
 
+describe('checkDestAddrIsValid', () => {
+	it('Should correctly throw an error when destAddr is an ethereum address and the destination is a system chain', () => {
+		const destAddr = '0x6E733286C3Dc52C67b8DAdFDd634eD9c3Fb05B5B';
+		const direction = Direction.ParaToSystem;
+
+		const err = () => checkDestAddrIsValid(destAddr, direction);
+
+		expect(err).toThrow(
+			'`destAddr` must be a valid substrate address when the destination chain is not a Parachain or Ethereum.',
+		);
+	});
+	it('Should correctly not throw an error when destAddr is a substrate address and the destination is a system chain', () => {
+		const destAddr = '5HBuLJz9LdkUNseUEL6DLeVkx2bqEi6pQr8Ea7fS4bzx7i7E';
+		const direction = Direction.ParaToSystem;
+
+		const err = () => checkDestAddrIsValid(destAddr, direction);
+
+		expect(err).not.toThrow();
+	});
+	it('Should correctly not throw an error when the destAddr is an ethereum address and the destination is a parachain', () => {
+		const destAddr = '5HBuLJz9LdkUNseUEL6DLeVkx2bqEi6pQr8Ea7fS4bzx7i7E';
+		const direction = Direction.SystemToPara;
+
+		const err = () => checkDestAddrIsValid(destAddr, direction);
+
+		expect(err).not.toThrow();
+	});
+});
+
 describe('checkParaAssets', () => {
 	it('Should correctly resolve when a valid symbol assetId is provided', async () => {
 		const assetId = 'xcUSDt';
diff --git a/src/errors/checkXcmTxInputs.ts b/src/errors/checkXcmTxInputs.ts
index c3e38d6f..e24dec00 100644
--- a/src/errors/checkXcmTxInputs.ts
+++ b/src/errors/checkXcmTxInputs.ts
@@ -28,6 +28,28 @@ import { validateNumber } from '../validate';
 import { BaseError, BaseErrorsEnum } from './BaseError';
 import type { CheckXcmTxInputsOpts } from './types';
 
+/**
+ * Ensure `destAddr` is a non ethereum address when the destination is a System or Relay chain.
+ *
+ * @param destAddr
+ * @param direction
+ */
+export const checkDestAddrIsValid = (destAddr: string, direction: Direction) => {
+	if (
+		isEthereumAddress(destAddr) &&
+		(direction === Direction.RelayToSystem ||
+			direction === Direction.SystemToSystem ||
+			direction === Direction.SystemToRelay ||
+			direction === Direction.ParaToSystem ||
+			direction === Direction.ParaToRelay)
+	) {
+		throw new BaseError(
+			'`destAddr` must be a valid substrate address when the destination chain is not a Parachain or Ethereum.',
+			BaseErrorsEnum.InvalidInput,
+		);
+	}
+};
+
 /**
  * Ensure when sending tx's to or from the relay chain that the length of the assetIds array
  * is zero or 1, and contains the correct token.
@@ -1125,6 +1147,8 @@ export const checkXcmTxInputs = async (baseArgs: XcmBaseArgsWithPallet, opts: Ch
 	} = opts;
 	const relayChainInfo = registry.currentRelayRegistry;
 
+	checkDestAddrIsValid(destAddr, direction);
+
 	/**
 	 * Require `sendersAddr` and `xcmFeeAsset` when dryRunCall option is true
 	 */