MIS-C Manuscript analysis and figures

Table of contents

• General info
• Dependencies
• Repo description
• Omics integration
• Setup

General info

Publication: "The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19"

This project used multiple omics data:

• Plasma protein expression (Olink - NPX values)
• FACS
• Autoantibodies

Dependencies

Project is created with:

• RStudio version: 3.6.2

Repo description

• Figure*.R reproducible code for figures laid out in manuscript

Omics integration

MOFA

• Multi-Omics Factor Analysis (MOFA+) was used in this study in order to deconvolute the main sources of variation in the differents sets of data mentioned above. For more information, read their published Methods paper Argelaguet et al. (2020).
• MOFA is publicly accessible here: https://github.com/bioFAM/MOFA2

Setup

To run this project, install it locally using devtools:

$ install.packages('devtools')
$ library(devtools)
$ install_github('Brodinlab/MIS-C_manuscript')
$ library(MIS-C_manuscript)